\

Not alive, but not dead: disembodied human brains used for drug testing

130 points - today at 7:38 PM

Source
  • hungryhobbit

    today at 11:43 PM

    I think most people agree: potentially torturing human brains is bad.

    I think most people also agree: torturing pets is bad too. Maybe like a 1/10th as bad as torturing humans, but still bad.

    Yet despite all that, we MASS TORTURE MILLIONS OF NON-PET ANIMALS EVERY YEAR ... just so we can all have cheaper Big Macs.

    P.S. If you disagree with the above, I strongly encourage you to prove how right you are, by researching what factory farming is, how widespread the practice is, and whether what they do to their animals amounts to torture. Please, look that up and "prove me wrong".

      • c420

        today at 11:50 PM

        Is there really a distinction between torturing humans and torturing pets? Aside from torture being torture, pets are members of people's families!

    • aetherspawn

      today at 8:48 PM

      Live dissection and experimentation on “alive but drugged” human brains is mental. How do you ensure that you aren’t torturing a brain that can’t see, hear or scream? How are you held accountable?

        • dhosek

          today at 10:20 PM

          When I had my ear surgery about 20 years ago, the doctor explained to me that I would be awake for part of the procedure, but the anesthesia meant that I would have no memory of it.¹ It’s a weird thing to think about whether that lack of memory would obviate the pain or discomfort of the moment.

          ⸻

          1. As it turned out, I was so frightened in the lead-up to the surgery that they had to do general anesthesia on me because I was shaking too much for them to operate so I was unconscious for the whole thing.

            • yoyohello13

              today at 10:49 PM

              Purely anecdotal, but I had surgery a few years ago (relatively minor). But I could feel for months after a sort of 'unconscious PSTD' I don't know how else to describe it. Even after it was healed and the pain was gone, there was just a deep sense of 'something bad happened in there' feeling. I'd have dreams of someone digging around in my body. Anyway, it's all gone now, but a weird experience for sure.

            • Gooblebrai

              today at 11:50 PM

              > the doctor explained to me that I would be awake for part of the procedure, but the anesthesia meant that I would have no memory of it

              The short story "Transition Dreams" by Greg Egan touches on this concept

              • andy99

                today at 11:33 PM

                I had a dentist explain to me the same for getting my wisdom teeth out, as if it was a selling feature. At least for me, having my memory wiped is far more scary than just being put unconscious (or having some pain and a local anaesthetic).

                • VectorLock

                  today at 10:51 PM

                  I had the same thoughts "but won't i feel it THEN?" when I was getting an upper endoscopy. The anesthesiologist said you're in such a trance, dreamlike state plus with the inability to form memories its like you're not your real "consciousness" but something different. Sort of like your brain is in "limp mode" and its not really _you._ This was both comforting and slightly terrifying in a different way.

                    • TurdF3rguson

                      today at 11:23 PM

                      Obviously it would be worse if you remembered it, but the trauma is still there even if you don't. Ask Bill Cosby's victims.

                  • thih9

                    today at 10:41 PM

                    > so I was unconscious for the whole thing

                    Or so they claim - the patient would have no memory of that anyway.

                • garethsprice

                  today at 8:56 PM

                  From the article:

                  > The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures.

                    • Barbing

                      today at 9:15 PM

                      I recognized that anesthetic from its famous irresponsible use-

                      "Attention to the risks of off-label use of propofol increased in August 2009, after the release of the Los Angeles County coroner's report that musician Michael Jackson was killed by a mixture of propofol and the benzodiazepine drugs lorazepam, midazolam, and diazepam on 25 June 2009." https://en.wikipedia.org/wiki/Propofol

                      Used properly, however:

                      "To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental."

                        • stavros

                          today at 9:31 PM

                          Apparently MJ was taking propofol to sleep, which another commenter said was akin to "getting a haircut by undergoing chemo".

                            • hungryhobbit

                              today at 9:35 PM

                              Between what he did to children, and what his parents did to him, it's hard to really blame the guy for having extreme sleep problems though.

                                • applfanboysbgon

                                  today at 9:45 PM

                                  > what he did to children

                                  The media and the people who bought into their shameless attention-grabbing lies are the reason he had sleep problems. He was unanimously acquitted of all counts, but the media made his life into a living hell by consistently portraying him as a pedophile because it drove incredible engagement numbers. A justice system should be "innocent until proven guilty", and yet MJ was deemed guilty even after proven innocent. Longform read from an actually good journalist, if you care to learn for yourself: https://www.huffpost.com/entry/one-of-the-most-shameful_b_61...

                                    • openasocket

                                      today at 11:37 PM

                                      That article was written 16 years ago and misses a lot as a result. it doesn’t mention the new allegations, including those documented in Leaving Neverland. It also glosses over the accusations in the 1990s. It’s papered over that those allegations were lies, but he settled the lawsuit with them for over $23M.

                                        • applfanboysbgon

                                          today at 11:47 PM

                                          Settling isn't an admission of guilt. It's plausible that he wanted to avoid the media circus that would inevitably result, and given that fighting it out in court was significantly more damaging to his reputation than settling the 90s case was despite being exonerated, he was probably right to settle. The article does also touch on the indications that those allegations were also not credible, although it doesn't do a deep dive.

                                          I don't give much credence to new allegations. Where were these allegations when he was alive, and why are people still publishing documentaries? You don't need a documentary to make an allegation. They're doing it because they want to make money, then. Off a dead man, who can't defend himself.

                                      • iwontberude

                                        today at 10:12 PM

                                        I mean, he may have never done a sexual thing but his pedophilia was quite obvious and the degeneracy of parents to allow their children to spend the night in the bed of a grown man is not really good for society.

                                          • lukan

                                            today at 10:51 PM

                                            "he may have never done a sexual thing but his pedophilia was quite obvious"

                                            How is it obvious pedophilia, if you say he may have never done a sexual thing to them?

                                              • hilariously

                                                today at 11:04 PM

                                                because he paid families to sleep in beds and hang out with their children, this is not a normal adult man behavior, and defending it on the internet is weird.

                                                  • applfanboysbgon

                                                    today at 11:06 PM

                                                    There is a wide, wide range between "normal behaviour" and "sex offender". I'm fine with being weird, and have no qualms defending the right of other people to be weird.

                                                    Maybe he liked playing with children because adults are evil and only saw him as a moneybag to try to extricate a payday from. If he wasn't harming them, it's not my business.

                                                    • lukan

                                                      today at 11:12 PM

                                                      It is not normal adult behavior and he likely should have had therapy.

                                                      But it is not necessarily pedophilia. Because that means wanting to have sex with children.

                                                      The explanation I heard is he wanted to be close to children to compensate for his own lack of innocent childhood. Children don't do sexual intercourse. Now if he was a child in his mind, then I as a parent would surely not have gave my children to his care, but this is still something very different from child molesting.

                                              • jp_sc

                                                today at 10:56 PM

                                                And you know this because of your firsthand experience observing it... or because the media told you so? Considering how readily the media is willing to lie for engagement, the truth is more likely to be the opposite of what they report.

                                                • jvanderbot

                                                  today at 10:46 PM

                                                  According to you. (And me, but just saying, society is a big place to be homogenized)

                                          • malbs

                                            today at 10:34 PM

                                            Here's a podcast deep diving into what it was he did.

                                            https://www.youtube.com/watch?v=9J1JQaIrxRU

                                            • falsaberN1

                                              today at 9:48 PM

                                              It's not only not been proven, but the island man stuff and testimony of people like Culkin suggest he actually did the opposite of doing bad things to children and was most likely a scapegoat for the "elites" of Hollywood because of his race.

                                              At the very least drop an "allegedly" or something to make it sound a little tasteful.

                                          • poszlem

                                            today at 9:38 PM

                                            That "another commenter" was Robin Williams - https://www.youtube.com/shorts/fZkFooaaaSo

                                              • Barbing

                                                today at 10:44 PM

                                                Miss this brilliant man

                                                —

                                                Happy to’ve learn a URL trick on HN so I’ll reshare:

                                                https://www.youtube.com/v/fZkFooaaaSo

                                                • stavros

                                                  today at 9:42 PM

                                                  Oh wow, I can't believe he was on reddit!

                                      • joegibbs

                                        today at 10:58 PM

                                        I don't trust them to always give the brain propofol. The subject has no way of reacting because they have no body, so what are they going to do?

                                        • raffael_de

                                          today at 10:28 PM

                                          oh, look, seems like we found the guy who can define what consciousness is! and not just that ... he even knows the lower boundary of it, too.

                                            • trklausss

                                              today at 10:33 PM

                                              I think there is worlds between definitely defining what consciousness is, and what are some of the scenarios and conditions under which consciousness cannot ever happen.

                                              And on top of that, they put a sedative, just in case.

                                                • raffael_de

                                                  today at 10:37 PM

                                                  my comment was meant a little bit humorous.

                                          • 1234letshaveatw

                                            today at 9:12 PM

                                            I could've done without reading the word almost

                                              • pavel_lishin

                                                today at 9:24 PM

                                                That's before they apply the anaesthetic.

                                                  • today at 9:32 PM

                                                • hypfer

                                                  today at 9:17 PM

                                                  Honestly, there is so much terrible terrible terrible stuff going on in the world and happening to real people, I think it is safe to say that those brains are having a blast. Relatively speaking.

                                                  It just invokes a strong emotional response because it's so "abnormal", but if you think about it, there is so much more pain going on where no one bats an eye.

                                                  Perfectly avoidable pain even. So it's not even that aspect.

                                                  ___

                                                  OTOH, this is HN, I guess. Having empathy for real people would be harmful to the business model of most people's employers.

                                                  So instead, mostly performative outrage/empathy with something that is effectively dead can fill in that gap.

                                                    • wewtyflakes

                                                      today at 10:39 PM

                                                      > I think it is safe to say that those brains are having a blast

                                                      How could you possibly say that? You are positing that the brains are both conscious and happy. Both of those are leaps.

                                                      > It just invokes a strong emotional response because it's so "abnormal"

                                                      You are making an assumption about why people find this horrifying, and the assumption you made was uncharitable.

                                                      > OTOH, this is HN, I guess. Having empathy for real people would be harmful to the business model of most people's employers.

                                                      I do not see how people on HN being horrified by human brain experiments means they do not have empathy.

                                          • koolba

                                            today at 9:11 PM

                                            > Live dissection and experimentation on “alive but drugged” human brains is mental.

                                            There’s no such thing as live dissection. It’s vivisection.

                                            • rendx

                                              today at 10:11 PM

                                              It's still an open debate whether the seat of consciousness (or even simpler, perception) is the brain.

                                              see e.g. Wahbeh, H., Radin, D., Cannard, C., & Delorme, A. (2022). What if consciousness is not an emergent property of the brain? Observational and empirical challenges to materialistic models. Frontiers in psychology, 13, 955594. https://doi.org/10.3389/fpsyg.2022.955594

                                              https://en.wikipedia.org/wiki/Hard_problem_of_consciousness

                                              Same for memory, which is "needed" as well for your question to make sense. The more current theories assume memories are stored not only in the brain, but throughout the body.

                                              see e.g. Repetto, C., & Riva, G. (2023). The neuroscience of body memory: Recent findings and conceptual advances. EXCLI journal, 22, 191–206. https://doi.org/10.17179/excli2023-5877

                                              https://en.wikipedia.org/wiki/Body_memory

                                                • ywain

                                                  today at 10:35 PM

                                                  Ok, I only skimmed the paper but it seems like all of the "non-local phenomena" in support of their theory are basically psychic powers. Not exactly strong evidence.

                                                    • rendx

                                                      today at 10:45 PM

                                                      You're free to stop there. We can also turn it around, and I can ask you for any paper that details the theory of why the brain should be the location of consciousness.

                                                      I only gave one example and Wikipedia to start with. There's a lot of material out there if you're (rightfully) skeptical of that one paper. I don't even know what you're refering to as "their theory", as the way I read it, they're basically documenting various co-existing theories, and the authors don't disclose which one they find the most likely. I also don't see it as necessary for science to pick one; it's all about theories. I prefer documentation of all possible theories, and see no reason to dismiss one over the other unless they're disproven. I pointed to that paper, because any paper that talks about alternative theories shows the point I was making: We don't know yet. The point was not to claim that they've managed to put together good or bad arguments.

                                                        • ywain

                                                          today at 11:22 PM

                                                          Sure. We can't even agree on a good definition for "consciousness", we certainly don't know _how_ it works. I don't think there's a lot of debate around that specific point.

                                                          I'll try and read the paper more carefully after work, but my quick read was: they posit that consciousness might not be localized in the brain because if it were, then how would people be able to perform telepathy / remote viewing / future foresight? I can't assert that their non-local hypothesis is wrong, but I can pretty confidently say that the evidence they're using to back it up is unscientific BS.

                                                  • raffael_de

                                                    today at 10:32 PM

                                                    I believe to some extent that everything is conscious and that it's specifically our species' prized mental features that lessen it's level at least temporarily. purely esoterically the statement "a rock is more conscious than a human being" doesn't even seem too outrageous to me.

                                                    • echelon_musk

                                                      today at 10:22 PM

                                                      See also: Hridaya.

                                                  • pavel_lishin

                                                    today at 8:56 PM

                                                    Well, we know how to make living brains insensate - that's who we all make it through surgery.

                                                    Presumably they're doing something similar - or using some other well-understood mechanism - to ensure that's not the case.

                                                    > The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures. Bexorg obtains brains in partnership with organizations that procure donated organs for transplantation, and Vrselja says once families understand the company’s process and goals, their response is overwhelmingly positive.

                                                      • gavmor

                                                        today at 9:10 PM

                                                        That’s somewhat overstated.

                                                        We know anesthesia "works," and we know some of its molecular targets, but we do not fully know the mechanism by which it produces unconsciousness, ie whether anesthesia eliminates experience, or mainly blocks memory, report, and integrated neural processing.

                                                          • duskwuff

                                                            today at 10:03 PM

                                                            Anesthesia appears to be a fairly broad effect - anaesthetics work on plants, for example [1], even though they lack any neural tissue whatsoever. It would be extremely surprising if those effects were also targeted enough to halt only some types of brain activity.

                                                            [1]: e.g. https://doi.org/10.4161/psb.27886

                                                        • harimau777

                                                          today at 9:57 PM

                                                          My understanding was that we now believe that patients under anesthesia are often "awake" but the drugs prevent them from forming memories so they can't complain once the anesthesia wears off.

                                                          Is that incorrect?

                                                            • munificent

                                                              today at 10:29 PM

                                                              "Anesthesia" is a wider umbrella term than most people realize with many levels of sedation.

                                                              Under "general anesthesia", the patient is completely unconscious. They don't respond to any stimuli. In rare cases, some patients may have an adverse reaction and still retain some sensation, but that's very uncommon. My understanding is that we are certain that patients are actually unconscious (and not just unable to respond) because none of the other involuntary responses to trauma occur during surgery: elevated heart rate, etc. In short, you are simply not there for a while. This is what you get for most kinds of significant surgeries unless the surgery requires you to be awake (like brain surgery where they may need to ask you questions).

                                                              "Sedation" or "twilight sedation" is a lower level of anesthesia. You are somewhat conscious and can respond to commands from the doctor. But you are unable to form memories of what's happening and you're usually on something like fentanyl that makes you entirely OK with whatever it is they are doing to you. This is common for procedures like colonoscopies and endoscopies where the procedure is somewhat uncomfortable but where you aren't being cut open.

                                                              In general, anesthesiologists are trying to balance the goal of patient comfort against the risks of deeper levels of sedation.

                                                              • sgc

                                                                today at 10:26 PM

                                                                More like very rarely (1-2 per 1000), very partially aware. I could not find anything saying that it was common, and it appears cases of actual awareness to the point of having pain / trauma are far rarer still. People who have this tend to have foggy memories or other concrete PTSD symptoms after the fact. It does not appear to be the norm.

                                                                I still think this experimentation is absolutely insane and I strongly object because there is no way to get feedback from the "patient" after the fact. Since we have no real idea of what is happening, I believe we should err on the side of caution. "But they could consent beforehand" is not morally acceptable for intrinsically inhumane actions that take away fundamental human rights and dignity. So if you think this is possibly inhumane / potentially torture, it is an irrelevant point since true consent would be impossible.

                                                                • today at 11:22 PM

                                                                  • ziml77

                                                                    today at 10:26 PM

                                                                    That's how twilight anesthesia works. That's the kind you get when having something like wisdom tooth removal or an endoscopy. They want you to be responsive to instructions but completely relaxed and unable to form memories of the event.

                                                            • EA-3167

                                                              today at 9:05 PM

                                                              It's not a great article, and it glosses over the reality that if you hooked this brain up to an EEG it would show unequivocal brain death. CELLS of the brain are alive, but in terms of being able to function in any sort of coordinated way there that ship sailed minutes after the person who donated their organs died. The wave of depolarization that marks brain death isn't something we can reverse, and what's being done here is all about metabolism and structure rather than those much more subtle functions.

                                                              IMO the more questionable aspect of this entire operation is the use of "AI" to reach conclusions about how the test molecules are being metabolized, but that's a lot less compelling than implying that some company is somehow preserving life in a disembodied brain.

                                                                • genxy

                                                                  today at 9:36 PM

                                                                  > isn't something we can reverse

                                                                  Until you hook it up to a lightening rod in the top of a castle!

                                                                    • EA-3167

                                                                      today at 9:53 PM

                                                                      Just remember to be a good father, or things get really epic in a gothic sort of way.

                                                                  • DontBreakAlex

                                                                    today at 10:40 PM

                                                                    Everyone upvote this guy more, thanks

                                                                • kreyenborgi

                                                                  today at 9:07 PM

                                                                  Reminds me of a certain scene from KnausgĂĄrd's Morning Star.

                                                                  • crooked-v

                                                                    today at 9:04 PM

                                                                    The word "alive" is doing a lot of work here. A brain is pretty much permanently fried after five to fifteen minutes without oxygen, and these are donor brains, not some emergency brain extraction team, so the timeframe will be much longer than that. There might be 'life' left in there in the technical sense, but there's no 'person' left.

                                                                    • cj

                                                                      today at 9:58 PM

                                                                      I’ll volunteer to waive my rights here. Feel free to do whatever you wish with my brain once it’s detached from my body :)

                                                                      Can’t be worse than my organs being harvested for donation.

                                                                      • dostick

                                                                        today at 9:52 PM

                                                                        Brain does not have physical feelings, and with all other feelings cut off and not possible, even with consciousness it won’t be a horror scenario like in MetallicA’s “One”.

                                                                          • ceejayoz

                                                                            today at 10:30 PM

                                                                            People go crazy in solitary confinement, and they at least have senses left. I’m not sure I’m as confident as you on this one.

                                                                    • ethanrutherford

                                                                      today at 9:04 PM

                                                                      This makes me feel physically ill. It's like something straight out of a sci-fi dystopia, how did this get approved? Who determined that reinjecting biological activity into a human brain is definitely not some form of reanimation? If they're using heavy sedation to prevent electrical activity, is that not tacit admission they're not 100% sure that consciousness might return otherwise? How did this pass ethics review, or did they even bother?

                                                                        • DontBreakAlex

                                                                          today at 10:52 PM

                                                                          Dude we can't revive brains minutes after cardiac arrest, when they're inside their bodies, even when we're TRYING TO DO SO. You can think about "what if" if you like the though experiment, but seriously arguing that there's any way that brains could recover consciousness the next day because you gave them nutrients is like arguing that voyager could crash back on earth and injure someone after being flung backwards around a loose interstellar body.

                                                                      • acheron

                                                                        today at 8:45 PM

                                                                        “We are all aware that the senses can be deceived, the eyes fooled. But how can we be sure our senses are not being deceived at any particular time, or even all the time? Might I just be a brain in a tank somewhere, tricked all my life into believing in the events of this world by some insane computer? And does my life gain or lose meaning based on my reaction to such solipsism?”

                                                                        Project PYRRHO, Specimen 46, Vat 7 Activity recorded M.Y. 2302.22467 (TERMINATION OF SPECIMEN ADVISED)

                                                                          • gavmor

                                                                            today at 9:12 PM

                                                                            Give credit where credit is due: Descartes, Kant, Putnam, etc.

                                                                              • dhosek

                                                                                today at 10:25 PM

                                                                                Meditations on First Philosophy messed me up bad. All of Descartes’ reasoning about the inability to determine whether experience was real made complete sense to me. But when I got to where he started to try to build back reality, I didn’t buy it. I can only believe in reality by willfully forgetting Descartes.

                                                                                • sodaplayer

                                                                                  today at 9:31 PM

                                                                                  It'll be Brian Reynolds in this case. It's a quote from Sid Meier's Alpha Centauri.

                                                                                  • mattlondon

                                                                                    today at 9:37 PM

                                                                                    Hmm pretty sure I saw this in the thought traces of Claude the other day...

                                                                            • NDlurker

                                                                              today at 9:01 PM

                                                                              This is legal but I can't legally pay another adult for sex or take drugs that could harm me? And there are many restrictions on gambling. It's weird how some morals are legislated but not others.

                                                                                • Aboutplants

                                                                                  today at 9:09 PM

                                                                                  This provides humanity with a greater good than gambling

                                                                                    • throwaway613746

                                                                                      today at 9:49 PM

                                                                                      So did Nazi eugenics.

                                                                                        • adi_kurian

                                                                                          today at 10:44 PM

                                                                                          How so?

                                                                              • prewett

                                                                                today at 8:33 PM

                                                                                I just finished reading "That Hideous Strength" (CS Lewis) this weekend where they have a disembodied head kept "alive", and some convicts in the pipeline whose heads/brains, it is implied, will be experimented on similarly. Lewis was remarkably prophetic.

                                                                                  • renticulous

                                                                                    today at 9:06 PM

                                                                                    The Dust Theory in Permutation City by Greg Egan pushes the concept to bizarre levels.

                                                                                      • bicx

                                                                                        today at 10:19 PM

                                                                                        Greg Egan is a legend

                                                                                • cduzz

                                                                                  today at 9:05 PM

                                                                                  NEW VISTA, OUTER RIM—Just a cycle ago, the brain was in a living person. Now, hours after its first owner died, it sits on a slab draped in tubes that quiver as they pump liters of blood substitute and other fluids through the organ, supplying oxygen and removing waste. As far as anyone knows, with many of its key functions intact but maybe awarness muffled by drugs, the brain hovers between life and death. As people subject it to experimental drugs, sensors record the brain's reactions, capturing hundreds of data points on its cells, proteins, and physiology. Then, after 24 hours in this state, it will be sliced into hundreds of pieces for more detailed study.

                                                                                    • today at 11:55 PM

                                                                                  • abtinf

                                                                                    today at 8:55 PM

                                                                                    I will be removing my organ donor status. This is horrifying.

                                                                                      • pavel_lishin

                                                                                        today at 8:57 PM

                                                                                        It looks like the families have to agree to do this, before your brain can be donated:

                                                                                        > Bexorg obtains brains in partnership with organizations that procure donated organs for transplantation, and Vrselja says once families understand the company’s process and goals, their response is overwhelmingly positive.

                                                                                          • smeggysmeg

                                                                                            today at 10:23 PM

                                                                                            Until we find out otherwise. There have been multiple organ harvesting scandals lately. Informed consent has become a marketing concept, no longer a reality.

                                                                                              • tyre

                                                                                                today at 11:09 PM

                                                                                                Citation required. Specifically for a western country happening at any notable scale via organ donors.

                                                                                          • dnnddidiej

                                                                                            today at 10:36 PM

                                                                                            Can't the donor stipulate take anything but the brain?

                                                                                    • cogogo

                                                                                      today at 11:31 PM

                                                                                      I find it hard to believe the donors had any idea they were authorizing an experiment like this but sure hope I am wrong.

                                                                                      Reminds me of the Three Body Problem and sending a live brain to the cosmos because the tyranny of the rocket equation made a whole human impossible.

                                                                                      • unsupp0rted

                                                                                        today at 7:57 PM

                                                                                        "alive" is not a meaningful term. It makes sense only when you have blunt instruments to measure aliveness, like pulse, respiration, heart beat, etc.

                                                                                        Once you go much more granular, there's no particular spot to make a distinction between "alive" and "not alive", until you stop seeing any electrical, biochemical and mechanical activity of any kind, at which point you're basically saying "inert".

                                                                                          • oh_my_goodness

                                                                                            today at 10:02 PM

                                                                                            Is this dry humor and/or a deliberate attempt to make the reader even more horrified by the experiment? Or only a different sensibility from mine? No judgement. I just really can't tell.

                                                                                            • ceejayoz

                                                                                              today at 8:30 PM

                                                                                              And yet, "my child is alive" versus "my child is dead" have some… meaning.

                                                                                              • lapetitejort

                                                                                                today at 8:54 PM

                                                                                                With what we are learning about how gut flora, can a brain be considered conscious while detached from the digestive system?

                                                                                            • hokkos

                                                                                              today at 8:50 PM

                                                                                              I Have No Mouth, and I Must Scream.

                                                                                                • ReptileMan

                                                                                                  today at 10:01 PM

                                                                                                  We don't create the torment nexus, we are creating all the possible torment nexuses

                                                                                              • WalterBright

                                                                                                today at 9:10 PM

                                                                                                There is a documentary about this:

                                                                                                https://www.imdb.com/title/tt0052646/mediaviewer/rm713036545...

                                                                                                • artursapek

                                                                                                  today at 11:14 PM

                                                                                                  A nice reminder to not check the "organ donor" box at the DMV

                                                                                                  • ckemere

                                                                                                    today at 9:05 PM

                                                                                                    The obvious question I would have asked: given the concern that this may not be ethical if the brains are still “alive” AND the concern that a brain separated from the body probably doesn’t function these same, why wouldn’t we test things in living monkeys (instead of mice)???

                                                                                                    It seems that the likelihood is high that the right animal model would yield superior data???

                                                                                                    • jjk166

                                                                                                      today at 10:14 PM

                                                                                                      Let me add Johnny Got His Gun to the surprisingly large number of works that seem to anticipate exactly this premise.

                                                                                                      • acdbddh

                                                                                                        today at 9:06 PM

                                                                                                        To be honest, if my only other option was to be buried, I would love to let my brain be connected to some machine that try to keep it as alive-like as possible.

                                                                                                        Just please don't remove my brain before I'm 1000% certainly dead.

                                                                                                          • bsimpson

                                                                                                            today at 10:46 PM

                                                                                                            This is precisely why I've never been interested in being an organ donor.

                                                                                                            I don't remember where specifically I learned this, but I was taught that tissue has to be alive to be useful, so they harvest it when you're almost-dead. Having my last moments be being literally dismembered is not something I wish for my future self.

                                                                                                              • scratchyone

                                                                                                                today at 11:12 PM

                                                                                                                They will never remove tissue if you're still alive. This is the reason organ donation is most common in brain-death cases, because the tissue is still alive but you are entirely dead. As you point out, it would be horrible to dismember someone who is still alive and would certainly violate their oath.

                                                                                                                I hope this is a comforting answer, I choose to be an organ donor because of these details.

                                                                                                            • saalweachter

                                                                                                              today at 9:14 PM

                                                                                                              To some extent, volunteering for any sort of medical study is signing up to be tortured in the hopes that someone down the line might be saved by the research. Most cancer treatments, for instance, are objectively terrible to go through, and when you're testing and developing the protocols you're pumping already sick people full of poisons and hoping for the best.

                                                                                                              There's some fraction of people who would prefer to be kept alive as a brain in a jar, depending on the alternatives, but getting to that point is going to require a bunch of people to volunteer to undergo excruciating torture as we learn how to keep the brain alive, how to keep them comfortable, how to keep them conscious, sane and let them interact with the world.

                                                                                                          • akomtu

                                                                                                            today at 10:54 PM

                                                                                                            That's demonic creativity.

                                                                                                            • aussieguy1234

                                                                                                              today at 11:10 PM

                                                                                                              Does this tech take us one step closer to a human brain in a robot body, or some kind of simulated reality?

                                                                                                              • kypro

                                                                                                                today at 10:05 PM

                                                                                                                This is literally my biggest fear. The idea that my biology or consciousness could be keep alive and in a state of suffering for years, decades, centuries or longer via neural simulation or biological intervention.

                                                                                                                I do wonder if AI advancements will allow me to see these horrors play out. Hopefully not to myself.

                                                                                                                https://spikeartmagazine.com/articles/libra-season-hello-cru...

                                                                                                                • ReptileMan

                                                                                                                  today at 9:57 PM

                                                                                                                  They have no mouth and they must scream...

                                                                                                                  • caconym_

                                                                                                                    today at 8:58 PM

                                                                                                                    What the fuck? This is beyond the pale.

                                                                                                                    • aftbit

                                                                                                                      today at 9:27 PM

                                                                                                                      “We'll send only a brain"

                                                                                                                      • jpwesselink

                                                                                                                        today at 8:54 PM

                                                                                                                        Just no.

                                                                                                                        • wrecked_em

                                                                                                                          today at 8:55 PM

                                                                                                                          [dead]